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. 2018 Sep 5;8:13281. doi: 10.1038/s41598-018-31548-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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All identified biomarkers and adapted hallmarks of cancer are summarized in the Ferris Wheel Plot. The area of each adapted hallmark of cancer represents the amount of articles with data on the corresponding hallmark of cancer. The most promising prognostic biomarkers according to our meta-analysis are highlighted. In the inner circle the hazard ratios (HR) and 95% Confidence Intervals (95%CI) are reported for each adapted hallmark of cancer.