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. 2018 Sep 3;109(9):2811–2821. doi: 10.1111/cas.13733

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© 2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effect of ENTPD8 on apoptosis and metabolites in two pancreatic cancer cell lines. A,B, Flow cytometry assay shows that ENTPD8 promoted cell apoptosis in both PANC‐1 and CFPAC‐1 cells. C‐E, Relative metabolite concentrations of CTP (C), cytidine monophosphate (CMP) (D) and cytidine (E) in cell lines. *P < .05, **P < .01 indicates statistical significance compared with the negative (NC) group. ^# P < .05, ^## P < .01, ^### P < .001 indicates statistical significance compared with pcDNA3.1‐NC group