Fig. 4. The combination reduces cell viability in multiple relapsed patient samples, but not in normal melanocyte in monolayer culture conditions.

ATP assays of melanoma patient samples and melanocytes with indicated treatments. The viability of the DMSO control for each cell line was set to 100%. The combination significantly (p ≤ 0.05) reduced cell viability compared with DMSO or with single drug treated conditions in all melanoma cell lines. For clarity, we marked only the combinational treatments that were significantly different from comparisons with the DMSO and the single drug treatments. Within each significant combination treatment, we only show the least significant p-value of the comparisons. * indicates p < 0.05; *** indicates p < 0.001