TABLE 4.
Whole-blood stability and RBC-to-plasma distribution ratios for cefepime, meropenem, piperacillin, and tazobactama
| Antibiotic | 15 min (T0) |
1 h (T1) |
2 h (T2) |
4 h (T3) |
RBC-to-plasma ratio | |||
|---|---|---|---|---|---|---|---|---|
| CV (%) | Difference from T0 (%) | CV (%) | Difference from T0 (%) | CV (%) | Difference from T0 (%) | CV (%) | ||
| Cefepime | 7.1 | 2.1 | 4.6 | −3.7 | 6.6 | −1.2 | 11.3 | 0.954 |
| Meropenem | 5.7 | 0.5 | 2.2 | −6.7 | 5.8 | −10.5 | 4.0 | 0.507 |
| Piperacillin | 3.9 | −0.1 | 3.8 | −0.2 | 5.2 | −1.2 | 3.5 | 0.306 |
| Tazobactam | 3.6 | 1.2 | 2.0 | 0.7 | 2.6 | 1.3 | 2.8 | 0.347 |
a
A concentration of 5 μg/ml was used for each antibiotic, and n = 6 for each antibiotic.