TABLE 1.
Bacterial susceptibility profile of NOSO-502 against reference bacterial strainsa
| Strain | MIC (μg/ml) of antibiotic |
|||||
|---|---|---|---|---|---|---|
| NOS | CIP | GEN | IPM | TGC | PMB | |
| Citrobacter freundii DSM 30039 | 2 | ≤0.125 | 0.5 | 1 | 1 | 0.5 |
| Citrobacter kozeri DSM 4595 | 2 | ≤0.125 | 0.25 | 4 | 1 | 0.25 |
| Enterobacter aerogenes DSM 30053 | 2 | ≤0.125 | 0.25 | 2 | 1 | 0.5 |
| Enterobacter cloacae DSM 14563 | 2 | ≤0.125 | 0.5 | 1 | 4 | 1 |
| Escherichia coli ATCC 25922 | 4 | ≤0.125 | 1 | 0.25 | 0.25 | 0.5 |
| Klebsiella pneumoniae ATCC 43816 | 1 | ≤0.125 | 0.25 | 1 | 2 | 1 |
| Serratia marcescens DSM 17174 | 4 | ≤0.125 | 0.5 | 2 | 4 | >32 |
| Acinetobacter baumannii ATCC 19606 | >64 | 2 | 16 | 0.5 | 1 | 0.5 |
| Pseudomonas aeruginosa DSM 1117 | >64 | 1 | 1 | 2 | >8 | 1 |
| Stenotrophomonas maltophilia ATCC 13637 | 16 | 1 | 4 | >64 | 0.5 | 1 |
| Enterococcus faecalis DSM 2570 | >64 | 2 | 16 | 1 | 0.25 | >32 |
| Enterococcus faecium DSM 20477 | 64 | 16 | 8 | 4 | 0.125 | >32 |
| Staphylococcus aureus ATCC 29213 | 1 | 0.25 | 0.5 | ≤0.125 | 0.5 | 16 |
| Staphylococcus epidermidis ATCC 12228 | 0.25 | 0.25 | ≤0.125 | ≤0.125 | 0.5 | 16 |
| Streptococcus pneumoniae DSM 2134 | 64 | 1 | 8 | ≤0.125 | 0.125 | >32 |
a
NOS, NOSO-502; CIP, ciprofloxacin; GEN, gentamicin; PMB, polymyxin B; IPM, imipenem; TGC, tigecycline.