TABLE 4.
Type of strain and gene mutation or gene conferring resistance (no. of isolates) | MIC range (μg/ml) |
|
---|---|---|
NOS | CSTa | |
Escherichia coli, colistin-resistant (25) | ||
mcr-1 (21) | 1–4 | 4–16 |
mcr-2 (1) | 1 | 8 |
mcr-3 (1) | 1 | 16 |
Unknown (2) | 1–2 | 16 |
Klebsiella pneumoniae, colistin resistant (46) | ||
pmrA G53S substitution (2) | 1–2 | 32–128 |
pmrB T157P substitution (6) | 0.25–16 | 8–32 |
pmrB L17Q substitution (1) | 1 | 32 |
phoQ R16C substitution (1) | 2 | >128 |
mgrB full deletion (5) | 0.5–1 | 16–>128 |
mgrB premature termination (6) | 0.5–1 | 32–128 |
mgrB IS5 between +74 and +75 (4) | 0.5–2 | 16–128 |
mgrB W20R substitution (1) | 0.5 | 32 |
mgrB W47R substitution (1) | 1 | 8 |
mgrB IS1R into promoter between −45 and −46 (3) | 0.5–1 | 32–128 |
mgrB M27K substitution (1) | 2 | 32 |
mgrB N42Y and K43I substitutions (1) | 2 | 32 |
mgrB ISKpn14 into promoter between −28 and −29 (2) | 0.5–2 | 64 |
mgrB IS903B between +69 and +70 (2) | 0.25–1 | 64 |
mgrB IS1R between +44 and +45 (2) | 1 | 128 |
mgrB ISKpn26-like between +74 and +75 (2) | 1 | 128–>128 |
crrB P151L substitution (1) | 128 | >128 |
crrB G183V substitution (1) | 64 | >128 |
crrB F84S substitution (1) | 8 | 128 |
crrB N141Y substitution (1) | 16 | >128 |
mcr-1 (1) | 0.5 | 32 |
Unknown (1) | 0.5 | 32 |
CST, colistin.