TABLE 4.

Bacterial susceptibility profile of NOSO-502 against colistin-resistant strains

Type of strain and gene mutation or gene conferring resistance (no. of isolates)	MIC range (μg/ml)
	NOS	CSTa
Escherichia coli, colistin-resistant (25)
mcr-1 (21)	1–4	4–16
mcr-2 (1)	1	8
mcr-3 (1)	1	16
Unknown (2)	1–2	16
Klebsiella pneumoniae, colistin resistant (46)
pmrA G53S substitution (2)	1–2	32–128
pmrB T157P substitution (6)	0.25–16	8–32
pmrB L17Q substitution (1)	1	32
phoQ R16C substitution (1)	2	>128
mgrB full deletion (5)	0.5–1	16–>128
mgrB premature termination (6)	0.5–1	32–128
mgrB IS5 between +74 and +75 (4)	0.5–2	16–128
mgrB W20R substitution (1)	0.5	32
mgrB W47R substitution (1)	1	8
mgrB IS1R into promoter between −45 and −46 (3)	0.5–1	32–128
mgrB M27K substitution (1)	2	32
mgrB N42Y and K43I substitutions (1)	2	32
mgrB ISKpn14 into promoter between −28 and −29 (2)	0.5–2	64
mgrB IS903B between +69 and +70 (2)	0.25–1	64
mgrB IS1R between +44 and +45 (2)	1	128
mgrB ISKpn26-like between +74 and +75 (2)	1	128–>128
crrB P151L substitution (1)	128	>128
crrB G183V substitution (1)	64	>128
crrB F84S substitution (1)	8	128
crrB N141Y substitution (1)	16	>128
mcr-1 (1)	0.5	32
Unknown (1)	0.5	32

^aCST, colistin.