TABLE 1.

Pharmacological parameters for AFX and IVM in plasma and in skin after oral administration to scabies-infested pigs^a

Sample type	Cmax (ng/ml)b	Tmax (days)c	AUCt-last (days · ng/ml)d	MRTC-last (days)e
Plasma
AFX	196 ± 160.2	0.4 ± 0.4	1,217.5 ± 751.5	7.1 ± 2.4
IVM	44.2 ± 11.6f	0.2 ± 0.0	38.7 ± 17.9	1.1 ± 0.2f
Skin
AFX	1,909.2 ± 962.4	1.25 ± 0.5	11,159.3 ± 6,158.4	16.2 ± 16.9
IVM	72.0 ± 40.2f	1.0 ± 0.0	186.2 ± 104.8	2.7 ± 0.5f

^aValues are presented as means ± SDs of AFX and IVM in the plasma and in the skin of pigs following oral intake.

^bC_max, maximum plasma concentration.

^cT_max, time to maximum plasma concentration.

^dAUC_t-last, area under the plasma curve concentration-time curve from time zero after first administration to the last sampling time point with a measurable concentration.

^eMRT_C-last, mean residence time.

^fP < 0.001 versus. AFX (compared with a nonparametric Mann-Whitney test).