TABLE 1.

Summary of demographic data and renal function in safety population at screening

Parameter	Data by renal function
	Mild impairment (n = 8)	Moderate impairment (n = 8)	Severe impairment (n = 8)	Normal (n = 8)	All (n = 32)
Age (yr)
Mean ± SD	70 ± 4	71 ± 8	64 ± 13	60 ± 9	66 ± 10
Median	71	74	70	59	70
Range	63–75	52–77	43–77	50–75	43–77
Ht (cm)
Mean ± SD	170 ± 5	172 ± 5	170 ± 6	177 ± 7	172 ± 6
Median	168	172	170	176	171
Range	165–180	163–180	161–184	168–188	161–188
Wt (kg)
Mean ± SD	75.2 ± 9.4	79.8 ± 14.6	75.8 ± 7.0	86.0 ± 12.4	79.2 ± 11.5
Median	74.1	80.1	77.8	83.3	77.8
Range	62.6–95.1	58.2–108.8	64.3–86.9	72.0–104.0	58.2–108.8
Body mass index (kg/m2)
Mean ± SD	26.2 ± 3.9	27.0 ± 4.3	26.3 ± 2.9	27.3 ± 2.7	26.7 ± 3.4
Median	25.1	27.4	26.2	26.4	26.3
Range	22.4–34.9	20.1–33.6	22.5–30.1	24.3–32.2	20.1–34.9
Creatinine clearance at screening (ml/min)
Mean ± SD	62.4 ± 4.5	41.5 ± 4.2	24.9 ± 3.5	94.5 ± 12.5
Median	61.5	40.0	25.5	93.0
Range	54.0–69.0	36.0–48.0	17.0–29.0	81.0–120.0
eGFR at screening (ml/min/1.73 m2)a
Mean ± SD	71.6 ± 15.3	39.5 ± 11.9	17.9 ± 2.5	81.4 ± 10.3
Median	73.0	36.0	18.0	81.0
Range	45.0–92.0	26.0–56.0	15.0–22.0	70.0–104.0
Race (no. [%])
Caucasian	8 (100)	8 (100)	8 (100)	8 (100)	32 (100)
Sex (no. [%])
Female	5 (62.5)	4 (50.0)	4 (50.0)	3 (37.5)	16 (50.0)
Male	3 (37.5)	4 (50.0)	4 (50.0)	5 (62.5)	16 (50.0)

^aeGFR, estimated glomerular filtration rate.