TABLE 2.

Primary and secondary pharmacokinetic characteristics

Parameter	Renal impairment group	na	Mean	SD	CV (%)b	Geometric mean	Geometric SD	Minimum	Median	Maximum
AUC0–∞ (h · mg/liter)	Mild	8	51.49	14.87	28.9	49.66	1.34	33.75	52.23	77.85
	Moderate	8	61.84	13.61	22.0	60.53	1.25	41.19	61.55	85.32
	Severe	8	71.13	12.85	18.1	69.99	1.22	47.26	74.02	85.64
	Healthy	8	27.52	42.80	15.6	27.23	1.16	23.19	26.21	33.63
Cmax (mg/liter)	Mild	8	6.47	1.48	22.9	6.32	1.26	4.40	6.30	8.97
	Moderate	8	6.82	0.74	10.9	6.78	1.12	5.54	6.96	7.89
	Severe	8	6.05	1.34	22.2	5.92	1.26	4.15	6.19	8.13
	Healthy	8	4.54	0.52	11.6	4.51	1.12	3.77	4.49	5.41
CL (liters/h)	Mild	8	3.4	0.8	22.1	3.3	1.2	2.6	3.2	4.7
	Moderate	8	2.9	0.3	11.7	2.9	1.1	2.1	2.9	3.2
	Severe	8	2.4	0.6	26.2	2.4	1.3	1.8	2.2	3.7
	Healthy	8	7.0	1.3	19.1	6.9	1.2	5.4	6.6	8.7
t1/2 (h)	Mild	8	14.1	2.6	18.5	13.9	1.2	11.2	13.1	18.1
	Moderate	8	15.9	4.0	25.2	15.5	1.3	11.6	14.9	22.0
	Severe	8	24.1	7.8	32.4	23.1	1.3	18.4	20.2	39.0
	Healthy	8	7.7	1.4	18.7	7.6	1.2	5.2	7.5	10.1
Vz (liters)	Mild	8	68.5	18.3	26.7	66.5	1.3	50.9	62.1	99.7
	Moderate	8	65.9	17.9	27.1	63.7	1.3	39.1	62.7	91.4
	Severe	8	80.9	17.9	22.1	78.9	1.3	54.4	82.2	101.6
	Healthy	8	76.3	14.1	18.5	75.3	1.2	65.1	68.3	99.2

^aNumber of evaluable subjects.

^bCV, coefficient of variation.