TABLE 2.
Linearitya
| Antibiotic | Linear equation (y = mx + b) |
Quadratic equation (y = ax2 + bx + c) |
R2 (mean ± SD) | Range (μg/ml) | |||
|---|---|---|---|---|---|---|---|
| Slope (mean ± SD) | Intercept (mean ± SD) | a (mean ± SD) | b (mean ± SD) | c (mean ± SD) | |||
| Meropenem | 0.511 ± 0.088 | 0.008 ± 0.014 | 0.997 ± 0.001 | 0.100–150 | |||
| Piperacillin | 0.398 ± 0.194 | 0.002 ± 0.006 | 0.997 ± 0.001 | 0.100–150 | |||
| Tazobactam | 0.117 ± 0.074 | 0.003 ± 0.006 | 0.997 ± 0.002 | 0.250–150 | |||
| Cefepime | 0.00019 ± 0.0005 | 0.037 ± 0.017 | −0.003 ± 0.008 | 0.996 ± 0002 | 0.500–150 | ||
a
For the linear equation, y represents the ratio of the peak area for the analyte to that for the IS, x represents the plasma concentration, m is the slope, and b is the intercept. For the quadratic equation, y represents the ratio of the peak area for the analyte to that for the IS, x represents the plasma concentration, a is the quadratic coefficient, b is the linear coefficient, and c is the intercept.