TABLE 5.
Matrix effect, extraction recovery, and hemolysis effecta
| Antibiotic | Concn (μg/ml) (QC level) | Matrix factor |
Extraction recovery |
Hemolysis effect |
|||
|---|---|---|---|---|---|---|---|
| Mean | CV (%) | Recovery (%) | CV (%) | Bias (%) | CV (%) | ||
| Cefepime | 1.50 (QC low) | 1.0 | 5.3 | 84.2 | 5.3 | 3.6 | 7.5 |
| 120.0 (QC high) | 1.0 | 0.8 | 108 | 0.8 | 4.6 | 3.0 | |
| Meropenem | 0.300 (QC low) | 0.8 | 6.3 | 115 | 6.3 | −1.0 | 7.8 |
| 120.0 (QC high) | 1.1 | 8.2 | 135 | 8.2 | −13.7 | 4.3 | |
| Piperacillin | 0.300 (QC low) | 1.0 | 7.2 | 102 | 7.2 | 4.4 | 11.9 |
| 120.0 (QC high) | 1.0 | 5.7 | 116 | 5.7 | −12.5 | 10.4 | |
| Tazobactam | 0.750 (QC low) | 1.0 | 8.3 | 83.3 | 8.3 | 11.6 | 7.8 |
| 120.0 (QC high) | 0.8 | 2.7 | 139 | 2.7 | −1.9 | 7.9 | |
a
n = 6 for each concentration of each antibiotic.