TABLE 2.

In vitro metabolism, protein binding, blood/plasma ratio, and plasma stability data for UCT943^a

Parameter	Value for the parameter (SD) in:
	Human	Dog	Rat	Mouse
Microsomal CLint (μl/min/mg)	<11.6 (0.1)	28.2 (0.5)	<11.6 (0.2)	<11.6 (0.7)
Hepatocyte CLint (μl/min/106 cells)b	<2	9	4	<4
Hepatocyte predicted EHb	<0.2	0.65	0.23	<0.2
fu microsomes	0.15 (0.01)	0.50 (0.04)	0.45 (0.05)	0.47 (0.04)
fu plasma	0.17 (0.009)	0.10 (0.007)	0.15 (0.009)	0.10 (0.02)
Blood/plasma ratio	1.5 (0.1)	2.3 (0.1)	2.1 (0.2)	1.9 (0.2)
Plasma stability (after 240 min) (%)b	97	95	97	102

^aPermeability across Caco-2 cells in both directions, P_{app B→A} and P_{app A→B}, was determined as (25 ± 5) × 10⁻⁶ cm/s and (28 ± 2) × 10⁻⁶ cm/s, respectively.

^bSingle determination.