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Predicted human PK parameters for UCT943 from modeling
| Parametera | Value for UCT943 |
|---|---|
| Plasma Vss (liters/kg) | 6.3 |
| Plasma CL (liters/h/kg) | 0.20 |
| MRT (h) | 32 |
| MPC (ng/ml) | |
| Plasma | 2.6 |
| Blood | 5.2 |
| ka (h−1) | 0.25 |
| F (%) | 80 |
| Single dose (mg)b | 50–80 |
| t1/2 (h) | 27 |
| Plasma AUC (ng · h/ml) | 4,213–8,223 |
| Plasma Cmax (ng/ml) | 234–358 |
MPC, minimum parasiticidal concentration; F, bioavailability.
Predicted single dose to achieve ≥8 days above the MPC.
