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. 2018 Aug 27;62(9):e01035-18. doi: 10.1128/AAC.01035-18

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FIG 3 — Antiviral activities of DTG, 4c, 4d, 4f, 6b, and 6p versus panels of INSTI-resistant mutants. The EC₅₀s were determined using a vector that carries the INSTI-resistant triple mutants in a single-round infection assay. The error bars represent the standard deviations of independent experiments; n = 4. (A) The EC₅₀s shown in the graph have a maximum value of 100 nM; values higher than 100 nM are not shown. The EC₅₀s of DTG against E138K/G140A/Q148K, 6b versus E138K/G140A/Q148K, and 4f against E138K/G140A/Q148K and E138K/G140C/Q148R INSTI-resistant triple mutants were >100 nM. (B) EC₅₀s of the INSTIs against a panel of INSTI-resistant triple mutants that included the G140S and Q148H primary mutations. The graph has a maximum value of 100 nM. The EC₅₀s of 6b versus T97A/G140S/Q148H and G140S/Q148H/N155H and 4f against T97A/G140S/Q148H and G140S/Q148H/N155H INSTI-resistant triple mutants were >100 nM. (C) EC₅₀s were determined against a panel of INSTI-resistant triple mutants that included a mutation at position N155 and two additional mutations. The EC₅₀s shown in the graph have a maximum value of 40 nM.