TABLE 5.
Population PK parameter estimates of the different β-lactam antibiotics from the one-compartment model
| Drug (n)a |
Vb |
CLc |
||||||
|---|---|---|---|---|---|---|---|---|
| Mean (liters) | CV (%) | Variance (liters) | Median (liters) | Mean (liters/h) | CV (%) | Variance (liters/h) | Median (liters/h) | |
| FEP (11) | 47.8 | 15.7 | 56.5 | 50.0 | 18.8 | 106 | 401.2 | 10.1 |
| CAZ (11) | 63.4 | 44.4 | 790.9 | 47.1 | 13.1 | 68.9 | 81.1 | 10.0 |
| PIP (89) | 56.3 | 30.4 | 293.2 | 49.6 | 26.8 | 52.4 | 197.1 | 25.9 |
| MEM (145) | 77.2 | 41.4 | 1,020.3 | 76.0 | 15.0 | 56.7 | 72.2 | 13.5 |
a
FEP, cefepime; CAZ, ceftazidime; PIP, piperacillin; MEM, meropenem; n, number of TDMs.
b
V, volume of distribution in the central compartment; CV, coefficient of variation.
c
CL, total body clearance.