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. 2018 Aug 27;62(9):e00752-18. doi: 10.1128/AAC.00752-18

FIG 4.

FIG 4

Effect of ceftriaxone (CTX) and ceftriaxone (CTX)-azithromycin (AZM) on plasma IL-6 (A), TNF-α (B), and IL-1β (C) levels in mice that underwent CLP. At 3 h after CLP challenge, mice were treated with vehicle, ceftriaxone (100 mg/kg, s.c.), or ceftriaxone (100 mg/kg, s.c.) plus azithromycin (100 mg/kg, i.p.), and the plasma cytokine levels were measured 18 h after CLP (n = 6). Data are expressed as the mean ± SEM (n = 6). ##, P < 0.01 for significance versus the sham-treated group; ###, P < 0.001 for significance versus the sham-treated group; *, P < 0.05 for significance versus the CLP group; **, P < 0.01 for significance versus the CLP group; ***, P < 0.001 for significance versus the CLP group.