TABLE 2.
MICs of various antimicrobials in wild-type A. baumannii ATCC 17978 and the abaQ mutant derivative
| Antimicrobial | MIC (mg/liter) |
Fold changea | MIC (mg/liter) |
Fold changeb | ||
|---|---|---|---|---|---|---|
| WT | AbaQ− | AbaQ− plus pET-RAØ | AbaQ− plus pET-RA+AbaQ | |||
| Ciprofloxacin | 0.25 | 0.0078 | 32 | 0.0078 | 0.25 | 32 |
| Levofloxacin | 0.125 | 0.0078 | 16 | 0.0078 | 0.125 | 16 |
| Nalidixic acid | 8 | 1 | 8 | 1 | 8 | 8 |
| Trimethoprim | 16 | 4 | 4 | 4 | 16 | 4 |
| Novobiocin | 8 | 4 | 2 | 4 | 8 | 2 |
| Meropenem | 2 | 2 | 1 | 2 | 2 | 1 |
| Ampicillin | 16 | 16 | 1 | 16 | 16 | 1 |
| Amikacin | 1 | 1 | 1 | 1 | 1 | 1 |
| Gentamicin | 0.5 | 0.5 | 1 | 0.5 | 0.5 | 1 |
| Erythromycin | 4 | 4 | 1 | 4 | 4 | 1 |
| Colistin | 0.5 | 0.5 | 1 | 0.5 | 0.5 | 1 |
| Chloramphenicol | 16 | 16 | 1 | 16 | 16 | 1 |
| Tetracycline | 4 | 4 | 1 | 4 | 4 | 1 |
| Minocycline | 0.062 | 0.062 | 1 | 0.062 | 0.062 | 1 |
| Rifampin | 4 | 4 | 1 | NAc | NA | NA |
a
Ratio of the MICs of the wild type (WT) versus abaQ mutant derivative (AbaQ−).
b
Ratio of the MICs for the abaQ mutant carrying the pET-RA+AbaQ plasmid (complemented mutant) versus the abaQ mutant carrying the empty pET-RA plasmid (pET-RAØ).
c
NA, not applicable (the pET-RA plasmid carries rifampin resistance).