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Probability of pharmacodynamic target attainment in plasma as a function of isolate MIC and fluconazole dosage. Each line represents the proportion of 5,000 simulated patients that achieve the PD target at the respective dosage (in milligrams) of fluconazole. The PD target was a plasma AUC/MIC ratio of ≥389.3. Bars show the proportion of WT strains of C. neoformans at the indicated MIC.
