Table 2.
Levels of CSF biomarkers in the different diagnostic groups.
| Control (n = 50) | PD (n = 131) | PDD (n = 27) | MSA (n = 24) | PSP (n = 14) | |
|---|---|---|---|---|---|
| α-syn ng/L | 152.7 (58.2) | 127.4 (42.6) | 143.4 (66.4) | 127.3 (60.0) | 115.0 (34.6) |
| Tau ng/L | 328.9 (116.6) | 257.6 (83.2)a | 310.3 (117.8)f | 325.1 (96.0)d | 274.0 (76.0) |
| P-tau ng/L | 52.2 (17.8) | 42.9 (13.2)b | 48.6 (16.9) | 38.9 (15.3)b,h | 43.3 (16.3) |
| Aβ42 ng/L | 641.1 (198.4) | 614.9 (158.9) | 552.1 (207.3) | 544.1 (176.5)c | 487.4 (158.8)c,e |
| NfL ng/L | 887.2 (724.0) | 870.2 (649.1) | 1515.4 (1242.4)a,d | 3502.0 (1932.7)a,d,g | 2617.3 (850.1)a,d,g |
| CRP ng/L | 3185.4 (3121.8) | 6097.2 (16120.7) | 11565.1 (14188.1)b,e | 14455.3 (28362.7)c,f | 8409.0 (9989.1) |
| SAA ng/L | 849.4 (818.4) | 3912.0 (26810.2)c | 6387.9 (14646.8)b,f | 7364.0 (24468.4)a,f | 3011.7 (4273.6)a,f |
| IL-6 ng/L | 0.586 (0.252) | 0.660 (0.336) | 0.815 (0.542) | 0.613 (0.205) | 0.684 (0.280) |
| IL-8 ng/L | 31.4 (8.7) | 35.8 (10.0)b | 39.7 (11.0)a | 38.1 (12.3)c | 44.4 (10.6)a,e |
| MCP-1 ng/L | 316.1 (76.6) | 338.6 (98.4) | 340.3 (107.5) | 383.1 (108.9) | 340.9 (65.9) |
| YKL-40 ng/L | 176839 (78368) | 152004 (53613) | 184126 (70721)f | 204501 (82161)e | 231208 (80495)c,d |
The data are presented as the mean and SD. Significance levels were analyzed using Mann-Whitney.
For α-syn only samples with Hb < 200 ng/L were used.
ap < 0.001 vs. controls; bp < 0.01 vs. controls; cp < 0.05 vs. controls.
dp < 0.001 vs. PD; ep < 0.01 vs. PD; fp < 0.05 vs. PD.
gp < 0.001 vs. PDD; hp < 0.05 vs. PDD.