Table 1.

Frequency of Mutations in the mtDNA ETC genes in Patients with AML (⁺denotes one patient with mutations in both ND1 and ND5).

Complex	Gene	Amino Acid Change	Mutation Type	No. of Patients
Complex I	ND1	Y43H+	Missense	1 (0.5%)
	ND2	—	—	—
	ND3	—	—	—
	ND4	—	—	—
	ND4L	—	—	—
	ND5	S345P, S476P	Missense	4 (2.0%)
		L260P+	Missense
		N452S	Missense
		P242Qfs*?	Truncating
	ND6	—	—	—
Complex III	CYB	V73M	Missense	3 (1.50%)
		M89I	Missense
		A302T	Missense
Complex IV	CO1	G435E	Missense	2 (1.0%)
		M237V	Missense
	CO2	L126S	Missense	5 (2.5%)
		D173N	Missense
		V191M	Missense
		T66A	Missense
		D112N	Missense
	CO3	L175P	Missense	2 (1.0%)
		V254A	Missense
ATP Synthase	ATP6	M60T	Missense	1 (0.5%)
	ATP8	—	—	—