Table 2.
Clinical characteristics of patients with AML according to mutational status of mitochondrial ETC genes.
| Characteristic | No Mutations (n = 184) | Mutations (n = 16) | p-value |
|---|---|---|---|
| Age, median (years) | 57 | 68.5 | 0.001 |
| Young (<60) | 106 (57.6%) | 3 (18.8%) | 0.003 |
| Old (≥60) | 78 (42.4%) | 13 (81.2%) | |
| Sex | 0.30 | ||
| Female (n, %) | 87 (47.3%) | 5 (31.3%) | |
| Male (n, %) | 97 (52.7%) | 11 (68.7%) | |
| FAB | |||
| M0 (n, %) | 15 (8.2%) | 4 (26.7%) | 0.04 |
| M1 (n, %) | 41 (22.4%) | 5 (33.3%) | 0.35 |
| M2 (n, %) | 41 (22.4%) | 3 (20%) | >0.99 |
| M3 (n, %) | 19 (10.3%) | 1 (6.25%) | >0.99 |
| M4 (n, %) | 39 (21.3%) | 2 (13.3%) | 0.74 |
| M5 (n, %) | 22 (12.0%) | 0 | 0.38 |
| M6 (n, %) | 3 (1.64%) | 0 | >0.99 |
| M7 (n, %) | 3 (1.64%) | 0 | >0.99 |
| WB Count, median | 15.6 | 21.5 | 0.79 |
| ln (WB Count) | 2.60 | 2.74 | 0.75 |
| % BM Blast, median | 72 | 77 | 0.69 |
| % PB Blast, median | 34.5 | 49 | 0.99 |
| Risk Status | |||
| Poor (n, %) | 43 (23.4%) | 8 (50.0%) | 0.035 |
| Intermediate (n, %) | 99 (53.8%) | 7 (43.8%) | 0.44 |
| Good (n, %) | 38 (20.7%) | 1 (6.25%) | 0.20 |
| Cytogenetic Status | 0.80 | ||
| Normal (n, %) | 85 (47.5%) | 7 (43.8%) | |
| Abnormal (n, %) | 94 (52.5%) | 9 (62.5%) | |
| Transplant (Y/N) | 0.79 | ||
| No (n, %) | 102 (55.4%) | 10 (62.5%) | |
| Yes (n, %) | 82 (44.6%) | 6 (37.5%) | |
P-values calculated using non-parametric Mann-Whitney U or Fisher’s Exact test.