Table 3.

Gene ontology and pathways enriched for potential candidate genes of CHL_milk^a.

Categoryb	Names	Number of genes	p-value
GO_BP	Cardiac muscle tissue development	4	1.00E-04
GO_BP	Positive regulation of cell-matrix adhesion	2	4.30E-04
GO_BP	Heart development	5	0.001
GO_BP	Negative regulation of protein ubiquitination	2	0.002
GO_BP	Striated muscle tissue development	4	0.002
GO_BP	Muscle tissue development	4	0.003
GO_BP	Ribosome biogenesis	4	0.003
GO_BP	Ventricular cardiac muscle morphogenesis	2	0.003
GO_BP	Regulation of cell-matrix adhesion	2	0.005
GO_BP	Cardiac muscle cell differentiation	2	0.005
GO_BP	Negative regulation of translation	2	0.005
GO_BP	Cardiac muscle tissue morphogenesis	2	0.005
GO_BP	Muscle tissue morphogenesis	2	0.005
GO_BP	Cardiac cell differentiation	2	0.005
GO_BP	Ribonucleoprotein complex biogenesis	4	0.006
GO_BP	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	2	0.006
GO_BP	Muscle organ development	4	0.006
GO_BP	rRNA processing	3	0.008
GO_BP	Negative regulation of cellular protein metabolic process	3	0.008
GO_BP	rRNA metabolic process	3	0.008
GO_BP	Regulation of protein ubiquitination	2	0.008
GO_BP	Negative regulation of protein metabolic process	3	0.009
GO_BP	Regulation of macromolecule metabolic process	21	0.009
GO_BP	Notch signaling pathway	2	0.009
GO_BP	Regulation of cell proliferation	7	0.009
GO_BP	Negative regulation of cellular process	11	0.009
GO_BP	Anatomical structure formation involved in morphogenesis	5	0.010
GO_CC	Anchored to membrane	5	0.001
GO_CC	Intracellular	66	0.006
GO_MF	Interleukin-2 receptor binding	2	8.60E-05
GO_MF	ATP-dependent helicase activity	5	2.50E-04
GO_MF	Purine NTP-dependent helicase activity	5	2.50E-04
GO_MF	Nucleic acid binding	31	0.002
GO_MF	Helicase activity	5	0.002
GO_MF	ATPase activity, coupled	6	0.006
GO_MF	3′–5′ exonuclease activity	2	0.006
KEGG	Glycerolipid metabolism	2	0.043
KEGG	Notch signaling pathway	2	0.045

^aCHL_milk: mg of cholesterol in 100 g of milk. Only gene ontologies with p-values < 0.01 are shown.

^bGO_BP: Biological processes gene ontology term, GO_CC: Cellular component gene ontology term and GO_MF: Molecular function gene ontology term.