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. 2018 Sep 5;8:13266. doi: 10.1038/s41598-018-31480-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Perpendicular component electrostatic force on the MTBD due to the E-hooks reels in and provides a soft landing for the MTBD. The electrostatic force component perpendicular to microtubule interface (the y direction, Fig. S1) plotted as a function of MTBD-microtubule distance. Note that the force for d = 0 Å was omitted from this analysis to avoid excessively large forces resulting from atoms positioned artificially too close to each other in the computation. Also note that the electrostatic force between MTBD and E-hooks was calculated by DelphiForce using all snap shots at each distance, and then the average value is reported here.