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. 2018 Sep 5;9:3593. doi: 10.1038/s41467-018-05803-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Involvement of Runx in regulating the helper-lineage dominant activity of E4m. a Dot plots showing CD4 and CD8 expression in lymph node T cells of mice with indicated genotypes. In Runx1/Runx3^ΔV/ΔV mice, both Runx1 and Runx3 proteins lack the VWRPY motif, which is essential for interaction with TLE/Groucho co-repressors. Right histograms showing CD4 expression level in CD8⁻ and CD8⁺ lymph node T cells of Cd4^{ΔE4p:S4M/ΔE4p:S4M} mice with (lower) or without (upper) Runx1/Runx3^ΔV/ΔV mutation. Numbers in quadrants indicate respective cell percentages. One representative result of three independent analyses. b Summary of percentage of CD4⁺ cells in CD8⁻ and CD8⁺ lymph node T cells of Cd4^ΔE4p/ΔE4p, Cd4^{ΔE4p:S4M/ΔE4p:S4M} mice with or without Runx1/Runx3^ΔV/ΔV mutation. Means ± SD. **p < 0.01 (unpaired student t test, two-sided). c Graph showing summary of three independent ChIP-qPCR for Runx bindings to E4p, S4, and E4m regions in DP thymocytes (DP) and CD8⁺ T cells from Cd4^+/+, Cd4^ΔS4/ΔS4 and Cd4^{ΔE4p:S4M/ΔE4p:S4M} mice. Means ± SD. *p < 0.05, **p < 0.01 (One-way ANOVA and Tukey’s multiple comparison test)