Figure 2.

Models for transcription regulation by CSB under different growth conditions. (Left) Under non-stressed conditions, CSB is targeted to TREs by the transcription factor c-Jun, where CSB can regulate transcription by both remodeling-dependent and -independent mechanisms. (Middle) Targeting of CSB by c-Jun to TREs also occurs in cells following oxidative stress with an up-regulation of c-Jun after stress (c-Jun*). Additionally, following oxidative stress, CSB is also enriched at binding motifs for the architectural protein CTCF. CSB may regulate 3D chromatin structure by modulating CTCF-chromosome interactions to regulate gene expression. (Right) Following UV irradiation and DNA repair, ATF3 is ubiquitinated in a CSB- and CSA-dependent manner and degraded by the proteasome, allowing RNA pol II recruitment and transcription reactivation.