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. 2018 May 10;46(15):7913–7923. doi: 10.1093/nar/gky372

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — SPiCE graphical ouput results on BRCA1/BRCA2 validation set (n = 160). Representation of variants according to their SSF-like and MES scores variations in percentage. Blue area represents variants with probability of splicing alteration under decision threshold of optimal sensitivity, red area corresponds to probability upper decision threshold of optimal specificity and gray area is probability between these two thresholds. Blue points are variants without splicing effect and red points are variants altering splicing.