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. 2018 Jun 25;46(15):7662–7674. doi: 10.1093/nar/gky536

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effect of EVI1-WT and EVI1-AQA on transcription. (A) Luciferase assays on promoters of EVI1-repressed PLZF (left panel) and FOS (right panel) transcripts (n = 4, t-test, ns: not significant). (B) Heat map illustration of significantly differentially expressed transcripts (P < 0.01) after transfection with EVI1-WT and EVI1-AQA of untreated cells (left half of the heatmap), and after treatment with H₂O₂ (150 μM, right half of the heat map, indicated by black line) (n = 1306). The heatmap was generated applying a group ANOVA analysis to the entire dataset. Clusters of EVI1 regulated transcripts were identified by dendrogram delineation, and boxed for repressed (1A and 1B), and upregulated transcripts (2A and 2B). Patterns of sub-clusters in H₂O₂ treated cells with different changes comparing EVI-WT with EVI1-AQA indicated by arrow in 1B and dashed box in 2B.