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. 2018 Aug 30;11:255. doi: 10.3389/fnmol.2018.00255

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Copyright © 2018 Wang, Xu, Lazarovici, Quirion and Zheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CREB as an integrative signaling molecule involved in schizophrenia. Dopamine stimulates the phosphorylation of CREB through D1R-mediated cAMP/PKA pathway or inhibits it through the D2R-mediated cAMP/PKA pathway. The CREB may also affect neurotrophins (BDNF) and other protein expressions and susceptibility genes associated with schizophrenia. The GWAS indicated that gene sets related to calcium channels, activity-regulated cytoskeleton-associated scaffold protein, FMRP, PSD-95, NMDA receptor, and synaptic proteins were potential candidates altered in the schizophrenic patients. The CREB-induced dysregulation in neuronal signaling may lead to neurodevelopmental deficits followed by schizophrenic behavior.