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. 2018 Jul 9;46(15):7731–7746. doi: 10.1093/nar/gky569

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Depletion of the central channel nucleoporins Nup54, Nup62 or Nup58 does not affect the nuclear import of 53BP1. (A) Fluorescence microscopy images of unirradiated HeLa cells 72 h after transfection with indicated siRNAs, showing 53BP1 (green) and DNA (DAPI, blue) staining. The arrow indicates perinuclear 53BP1 accumulation. (B) Quantification of 53BP1 nuclear levels (mean fluorescence intensity). Values shown in graph correspond to mean ± sd (*P < 0.001, two-sided t-test; n = 3 technical replicas from a representative experiment repeated three times).