Table II.

Selected treatment-associated adverse events (all grades).

Event	≥70 years	<70 years	P-value
Adverse event, %
Hypertension	64.3	61.9	0.8734
Hand-foot syndrome	35.7	47.6	0.4378
Stomatitis	57.1	40.5	0.2773
Fatigue	35.7	40.5	0.7520
Diarrhea	42.9	38.1	0.7520
Altered taste	14.3	45.2	0.0383
Edema	35.7	23.8	0.3837
Nausea	14.3	9.5	0.6179
Fever	14.3	9.5	0.6179
Cardiac dysfunction	7.1	4.8	0.7319
Cholecystitis	0	7.1	0.3040
Enteritis	0	2.4	0.5602
Nasal bleeding	0	2.4	0.5602
Laboratory abnormalities, %
Leukopenia	85.7	83.3	0.8336
Anemia	85.7	76.2	0.4520
Thrombocytopenia	92.9	92.9	–
Increased creatinine	50.0	45.2	0.7570
Increased alanine transaminase	14.3	9.5	0.6179
Increased alkaline phosphatase	0	4.8	0.4057
Increased lipase	0	9.5	0.2308
Hypothyroidism	50.0	64.3	0.3432
Proteinuria	64.3	78.6	0.2850