Table 8.

Reported Growth in NF-pNETs From Included Studies

Authors, Year	n	No pNETs	NF-pNET Size, mm	Design	Modality Used for Assessment	FU in Months	Size at First Detection (in mm Median)	Annual Growth (All Lesions; mm/y)	Incidence New Lesions (per pt/y)	Growth New Lesions (mm/y)
D’souza et al., 2014 [47]	11	18	NA	R	EUS	79 (18–134)	10.3 (5–24)	1.32	0.17	3.0
Kann et al., 2006 [48]	20	84	<15	P	EUS	20 ± 12	5.9 (1.5–14.5)	1.3% ± 3.2%/mm = 0.9 ± 2.3	0.62
Kappelle et al., 2017a [49]	38	226	<20	R	EUS	38.4 (1.1–5.6)b	5.0	0.10	0.79	No growth
Pieterman et al., 2017 [13]	99	115	<20	R	CT/MRI	156 (84–276)b	10 ± 4	0.4 Stable: no growth; progressive: 1.6	1.04
Triponez et al., 2017 [50]	46	96	<20	P	CT/MRI/EUS	128 ± 50,4	9.3 ± 5	Stable: <0.1; progressive: 0.54
Waldmann et al., 2009a [37]	29	88	NA	P	EUS	72 (24–108)	9.0	11.7 ± 24.1% = 1.1 ± 2.17 mm	0.52	1.28
Sakurai et al., 2007 [52]	14	26	NA	R	CT	78 ± 36	20 ± 18 (5–78)	Not reported	Not reported	Not reported

FU: median (range) or means ± SD. Size: median (range) or means ± SD.

Abbreviations: NA, not applicable; P, prospective study; R, retrospective study.

^aPopulation with NF-pNETs and (possibly) functional pNETs.

^bInterquartile range.