Table 9.

Data on Age-Related Penetrance (NF-pNETs) From Included Studies

Study	No. of MEN1 Patients (pNETs)	Design	Age, y	Modality Used	Penetrance	Youngest Patient, y
Gonçalves et al., 2014 [53]	19 (8)	R	12–20	EUS (74%) CT/MRI	42% NF-pNETs by age 20 y	16
Goudet et al., 2015 [54]	160	R	1–21	CT/MRI/EUS	9% NF-pNETs by age 21 y	13
Manoharan et al., 2017 [56]	166 (8)	P	8–18	MRI/EUS	1.8% NF-pNETs by age 19 y	15
Machens et al., 2007 [55]	258 (126)	Cross	43 (mean)	CT/MRI/EUS	Age-related penetrance dpNETs (NF-pNETs)	NA
					Mean age 14: 4% (0%)
					Mean age 33: 45% (18%)
					Mean age 48: 57% (14%)
					Mean age 64: 60% (13%)
Triponez et al., 2006 [7]	579 (108)	P		CT/MRI/EUS	Penetrance dpNET (NF-pNET)	NA
					Age 20: 9% (3%)
					Age 50: 53% (34%)
					Age 80: 84% (53%)
Thomas-Marques et al., 2006 [51]	51	P	39 (16–71)	EUS	Frequency: 54.9% in cohort	16

Abbreviation: Cross, cross-sectional.