AAV-Mediated Correction of Lysosomal Storage in Non-neuronal Tissues in Eyes and Peripheral Tissues
(A and B) MPS II mice were injected i.v. with 5 × 1012 vg/kg scAAV9-mCMV-hIDS at age 1 month. Eye (A) and peripheral tissues (B) were assayed at 7 months pi (age 8 months) by immunofluorescence for LAMP 1 (red fluorescence). Blue fluorescence indicates DAPI-stained nuclei. Con, cornea; Cil, ciliary process; Irs, iris; LIV, liver; BC, bronchiole; HRT, heart; KID, kidney. G, glomerulus.