Table 2.
Tumor Incidence in AAV9-Treated MPS II and Non-treated WT Mice
| Mice | Vector Dose (vg/kg) | Injection Age (Months) | Test Age (Months) | No. of Mice |
Tumor Rate (%) | p Valueb | |
|---|---|---|---|---|---|---|---|
| Necropsy | Tumorsa | ||||||
| WT | N/A | N/A | 14.7–30.7 | 25 | 9 | 36 | – |
| MPS II | 2.5 × 1012 | 1 | 20.1–29.4 | 7 | 4 | 57 | 0.314 |
| 5 × 1012 | 1 | 16.3–27.5 | 7 | 4 | 57 | 0.314 | |
| 5 × 1012 | 3 | 17.7–29.2 | 5 | 2 | 20 | 0.865 | |
| 5 × 1012 | 6 | 15.0–29.4 | 7 | 1 | 14 | 0.273 | |
| 1 × 1013 | 6 | 16.0–25.8 | 7 | 3 | 43 | 0.740 | |
| 2 × 1013 | 6 | 20.7–24.4 | 5 | 1 | 20 | 0.488 | |
| 2 × 1013 | 9 | 13.2–23.7 | 4 | 1 | 25 | 0.667 | |
| Total | – | – | – | 42 | 16 | 38.1 | 0.864 |
N/A, not applicable.
a
Gross and/or microscopic tumors.
b
p value versus WT rate by chi-square analysis.