Figure 3. Treatment of spontaneously hypertensive rats (SHR) with captopril improved renal histology. A, D, Wistar-Kyoto rats (WKY) at week 12 and week 20 showing no abnormal changes. B, SHR at week 12 with presence of minimal glomerular atrophy, fall-off of tubule epithelial cells, interstitial fibrosis, and increased thickness of basement membrane. E, SHR at week 20 showing significant pathological changes in the kidney. C, F, SHR+Captopril at week 12 and week 20 showing improvement of kidney histology. Magnification: 200×; bar: 100 μm. G, Renal injury scores (n=6 in each group). Data are reported as means±SE. **P<0.01 vs WKY; ##P<0.01 vs SHR (one-way ANOVA).
