Figure 5.

SND treatment upregulates NF-κB or CRE reporter activity in H295R cells. Adrenocortical H295R cells were stably transfected with luciferase-expressing reporter constructs responsive to either (A) NF-κB activity or (B) CRE binding protein activity. Luciferase activity was assessed following a 24-h treatment with SND. Values are expressed as the mean ± standard error of the mean (n=6/group). *P<0.01 vs. blank or Forskolin group. SND, Sini decoction; NF, nuclear factor; CRE, cyclic adenosine monophosphate response element.