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. 2018 Sep 5;11:113. doi: 10.1186/s13045-018-0656-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — NEAT1 promoted CRC cell proliferation in vitro and in vivo. a The baseline NEAT1 RNA levels in eight CRC cell lines detected by RT-qPCR. b The efficiency of NEAT1 knockdown or overexpression was detected by RT-qPCR in the indicated cells transfected with siRNAs or plasmids (*p < 0.05). c CCK8 and d EdU assays showing that knockdown of NEAT1 suppressed cell proliferation in the HCT116 and SW1116 cell lines (*p < 0.05) and that upregulation of NEAT1 promoted cell proliferation in the HT29 cell line (*p < 0.05). e Colony formation assays for the indicated cells after transfection with siRNAs or plasmids (*p < 0.05). The nude mouse xenograft model showed that knockdown of NEAT1 decreased tumor growth (f) and the tumor weights (g) compared with those of the HCT116-shNC cells (*p < 0.05). h Representative images of tumors in nude mice. i Representative images of IHC staining for ki-67 and DDX5 (Sc represents scramble)