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. 2018 Jul 23;16(4):3082–3088. doi: 10.3892/etm.2018.6512

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Intrathecal injection of IWP-2 relieved CCI-induced neuropathic pain and reduced neuronal synaptic plasticity. In total, 18 SD rats were randomly divided into treatment group, DMSO group and NC group. Bilateral sciatic nerve ligation was performed in the first two groups, and Wnt-3a inhibitor IWP-2 was intrathecally administered in treatment group. Rats in DMSO group were intrathecally injected with the isodose DMSO. Only intrathecal catheterization was performed in rats of NC group. Behavioral measurements were performed preoperatively, on the day of surgery, 3rd day and 5th day after IWP-2 treatment. (A-C) The changes of mechanical threshold, thermal stimulation threshold and cold stimulation threshold over time were observed (n=6). (D and E) The phosphorylation levels of CaMK II, NR2B, CREB, PKC and Src in each treatment group was detected by western blotting (n=3) (*P<0.05). CCI, chronic constriction injury.