Table 2.
Comparison of baseline brain MRI features between Japanese and Caucasian patients with MS
| Mean | Median (IQR) | Mean | Median (IQR) | p | |
|---|---|---|---|---|---|
| Japanese patients (n = 93) | Caucasian patients (n = 72) | ||||
| Number of T2W-lesions | 62 | 50 (27–96) | 73 | 65 (24–108) | 0.08 |
| T2W-lesion volumes (cm3) | 11.5 | 7.8 (2.3–16.9) | 8.0 | 5.3 (2.4–12.2) | 0.12 |
| Each T2W-lesion volume (mm3) | 174 | 140 (78–224) | 118 | 85 (63–138) | < 0.0001 |
| Japanese patients (n = 83) | Caucasian patients (n = 233) | ||||
| NBV (cm3) | 942.6 | 954.1 (903.9–980.2) | 972.9 | 977.9 (940.4–1002.6) | < 0.0001 |
| Japanese patients (n = 45) | Caucasian patients (n = 148) | ||||
| NWMV (cm3) | 467.4 | 466.1 (446.5–486.1) | 486.9 | 487.7 (473.2–501.4) | < 0.0001 |
| Japanese patients (n = 52) | Caucasian patients (n = 165) | ||||
| NCGMV (cm3) | 441.3 | 438.3 (418.6–473.1) | 449.8 | 452.0 (429.9–471.7) | 0.08 |
| Japanese patients (n = 73) | Caucasian patients (n = 207) | ||||
| NDGMV (cm3) | 37.0 | 36.7 (33.3–40.6) | 40.8 | 41.4 (38.0–43.8) | < 0.0001 |
| Normalized thalamic volume (cm3) | 17.2 | 17.3 (15.7–19.0) | 18.8 | 18.9 (17.6–20.2) | < 0.0001 |
Statistical comparisons were performed using linear regression with adjustments for age, sex, duration of disease from the first symptom, and exposure to previous MS treatment. We calculated the average T2W-lesion volume by dividing overall T2W-lesion volume by the number of T2W-lesions in individual patients
IQR interquartile range, MRI Magnetic resonance imaging, MS multiple sclerosis, NBV normalized brain volume, NCGMV normalized cortical gray matter volume, NDGMV normalized deep gray matter volume, NWMV normalized white matter volume