Table 3.
c.103G > T (p.Val35Leu) and c.1694C > T (p.Pro564Leu) Variants in aSAH subtypes
| Variable | Case | Val/Val (p) | Val/Leu (p) | Leu/Leu (p) | Val | Leu | Val Vs Leu (p) | Pro/Pro (p) | Pro/Leu (p) | Leu/Leu (p) | Pro | Leu | Pro Vs Leu (p) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | 200 | 180 | 18 | 2 | 378 | 22 | 92 | 74 | 34 | 258 | 142 | ||
| Site of Aneurysm | |||||||||||||
| ACOM | 86 | 75(0.86) | 11(0.38) | 0(0.62) | 161 | 11 | 0.67 | 42 (0.79) | 26 (0.44) | 18(0.51) | 110 | 62 | 0.90 |
| PCOM | 12 | 11(0.96) | 1(0.94) | 0(0.45) | 23 | 1 | 0.78 | 4 (0.58) | 7(0.35) | 1(0.50) | 15 | 9 | 0.84 |
| ICA | 36 | 32(0.96) | 3(0.90) | 1(0.40) | 67 | 5 | 0.62 | 16(0.91) | 16(0.57) | 4(0.44) | 48 | 24 | 0.72 |
| MCA | 37 | 36(0.76) | 1(0.24) | 0(0.96) | 73 | 1 | 0.16 | 14 (0.56) | 17(0.50) | 6(0.92) | 45 | 29 | 0.54 |
| Multiple | 22 | 20(0.97) | 2(0.98) | 0(0.71) | 42 | 2 | 0.79 | 13 (0.50) | 6(0.52) | 3(0.73) | 32 | 12 | 0.27 |
| Basilar top | 7 | 6(0.93) | 0(0.82) | 1(0.03) | 12 | 2 | 0.18 | 3 (0.91) | 2(0.75) | 2(0.52) | 8 | 6 | 0.57 |
| Size of aneurysm | |||||||||||||
| Small(< 15 mm) | 159 | 141(0.92) | 17(0.62) | 1(0.70) | 299 | 19 | 0.78 | 76(0.83) | 55(0.74) | 28(0.89) | 207 | 111 | 0.86 |
| Large(15-25 mm) | 37 | 36(0.76) | 0 | 1(0.42) | 72 | 2 | 0.32 | 15(0.70) | 17(0.50) | 5(0.65) | 47 | 27 | 0.87 |
| Giant(> 25 mm) | 4 | 3(0.81) | 1(0.37) | 0 | 7 | 1 | 0.41 | 1(0.58) | 2 (0.73) | 1(0.73) | 4 | 4 | 0.40 |
| WFNS Grade | |||||||||||||
| Grade I | 91 | 82(0.99) | 8(0.95) | 1(0.93) | 172 | 10 | 0.99 | 38(0.67) | 31(0.73) | 22(0.24) | 107 | 75 | 0.18 |
| Grade II | 42 | 36(0.84) | 5(0.59) | 1(0.48) | 77 | 7 | 0.32 | 21(0.77) | 17(0.77) | 4(0.29) | 59 | 25 | 0.31 |
| Grade III | 51 | 47(0.91) | 4(0.81) | 0 | 98 | 4 | 0.52 | 26(0.71) | 20(0.40) | 5(0.27) | 72 | 30 | |
| Grade IV | 16 | 15(0.91) | 1(0.73) | 0 | 31 | 1 | 0.57 | 7(0.91) | 6(0.97) | 3(0.88) | 20 | 12 | 0.82 |
| Male | 77 | 73(0.78) | 4(0.33) | 0 | 150 | 4 | 0.15 | 39(0.68) | 26(0.72) | 12(0.81) | 104 | 50 | 0.50 |
| Female | 123 | 107(0.14) | 14(0.53) | 2(0.62) | 228 | 18 | 0.35 | 53(0.75) | 48(0.80) | 22(0.86) | 154 | 92 | 0.62 |
| Hypertension (+) | 37 | 32(0.33) | 5(0.44) | 0 | 69 | 5 | 0.66 | 14(0.56) | 18(0.38) | 5(0.65) | 46 | 28 | 0.70 |
| Diabetes mellitus (+) | 71 | 65(0.93) | 5(0.63) | 1(0.78) | 136 | 7 | 0.78 | 34(0.86) | 25(0.85) | 12(0.98) | 93 | 49 | 0.83 |
| Alcohol (+) | 57 | 53(0.88) | 4(0.66) | 0 | 110 | 4 | 0.39 | 29(0.69) | 18(0.60) | 10(0.93) | 76 | 38 | 0.66 |
| Smoking (+) | 58 | 54(0.87) | 4(0.64) | 0 | 112 | 4 | 0.37 | 31(0.55) | 19(0.68) | 8(0.61) | 81 | 35 | 0.28 |
p-value < 0.05 are given in bold