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. 2018 Sep 5;10:115. doi: 10.1186/s13148-018-0550-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Model of epigenetic regulation of MAGEs in cancer progression. MAGE family can be activated by DNA hypomethylation, histone acetylation, histone methylation, and nucleosome depletion, eventually contributing to oncogenesis. At the same time, MAGEs might be regulated by ceRNA network through miRNAs as the mediators.