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. 2018 Sep 5;13:227. doi: 10.1186/s13018-018-0934-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schema of the time course. Time 0 was defined as when the infusion of propofol started. Muscle relaxant was administered only upon propofol induction. A small amount of inhalation anesthetic (sevoflurane, 0.8 to 8.0%) was used for anesthetic induction in 44 pediatric cases. Anesthesia was maintained with continuous infusion of propofol and remifentanil. Star marker, start of surgery; MEP, motor evoked potential; TCI, target-controlled infusion (a device to deliver the drug to achieve specific predicted target drug concentrations in the blood); BIS, bispectral index (a device to assess the depth of anesthesia)