Table 1.
Effect of phillygenin/OFE on AST, ALT, SOD, and MDA activities in blood serum of normal and experimental mice (n = 6).
|
ALT (nmol/(s L)) |
AST (nmol/(s L)) |
SOD (U/mg protein) |
MDA (nmol/mg protein) |
|
|---|---|---|---|---|
| normal control | 42.0 ± 7.26 | 183 ± 16.8 | 52.8 ± 4.90 | 1.75 ± 0.482 |
| CCl 4 control | 271 ± 92.0∗∗ | 278 ± 35.6∗∗ | 39.2 ± 5.17∗∗ | 2.54 ± 0.251∗∗ |
| positive control | 70.0 ± 18.3## | 186 ± 10.4## | 47.2 ± 2.95## | 1.81 ± 0.270## |
| 150 mg/kg OFE | 111 ± 43.1## | 175 ± 15.5## | 46.5 ± 4.25# | 1.82 ± 0.541# |
| 300 mg/kg OFE | 109 ± 23.2## | 171 ± 30.4## | 45.9 ± 2.65# | 1.79 ± 0.250## |
| 600 mg/kg OFE | 99.0 ± 25.7## | 178 ± 24.9## | 46.5 ± 3.63# | 1.76 ± 0.430## |
| 6 mg/kg phillygenin | 111 ± 30.5## | 190 ± 29.2## | 46.4 ± 4.27# | 1.85 ± 0.820 |
| 12mg/kg phillygenin | 112 ± 23.1## | 196 ± 28.4## | 46.9 ± 2.74## | 1.91 ± 0.224## |
| 24 mg/kg phillygenin | 110 ± 16.4## | 192 ± 20.8## | 49.5 ± 6.89# | 1.92 ± 0.413# |
∗ p < 0.05, ∗∗ p < 0.01 versus normal control group.
# p < 0.05, ## p < 0.01, versus CCl4 control group.