Table 2.
Pharmacokinetic parameters of phillygenin after single oral (24 mg/kg) or iv (12 mg/kg) to mice.
| Parameter | po (24 mg/kg) | iv (12 mg/kg) |
|---|---|---|
| A U C 0-last ( μg·min/mL) | 71.3 | 63.2 |
| A U C 0-∞ ( μg·min/mL) | 72.5 | 76.2 |
| Vd (mL/kg) | c NC | 300 |
| CL (mL/min/kg) | 345 | 156 |
| C 0 (μg/mL) | bNQ | 3.14 |
| C max (μg/mL) | 0.7 | - - |
| T max (min) | 30 | - - |
| t (1/2)α (min) | c NC | 3.78 |
| t (1/2)β (min) | cNC | 630 |
| A Half-life (min) | 54.8 | - - |
| D Half–life (min) | 150 | a NC |
| E Half-life (min) | 240 | aNC |
| F (%) | 56.4 | - - |
aNC = not calculated; low levels did not allow calculation of terminal half-life and AUClast-∞.