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. 2018 Sep;13(9):1575–1584. doi: 10.4103/1673-5374.237121

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Copyright: © Neural Regeneration Research

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Effect of sevoflurane exposure in mid-gestation on VEGF, PI3K, AKT and p-AKT levels in the fetal brain 6 hours after anesthesia.

(A) Western blots for VEGF, PI3K, AKT and p-AKT in the fetal brain. (B) Quantitation of VEGF, PI3K, AKT and p-AKT levels in the fetal brain in the three groups. Data are expressed as the mean ± SD (n = 8 mothers, with 3 rats per mother as replicates). *P < 0.05, vs. C GROUP (one-way analysis of variance followed by the Bonferroni post hoc test). C GROUP: Control group; L GROUP: low-concentration sevoflurane (2%) group; H GROUP: high-concentration sevoflurane (3.5%) group. VEGF: Vascular endothelial growth factor; PI3K: phosphatidylinositol 3-kinase; p-AKT: phospho-AKT.