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. 2018 Sep;13(9):1657–1664. doi: 10.4103/1673-5374.232530

Figure 1.

Figure 1

Change in pain threshold in diabetic neuropathic (DN) rats at analgesimeter (A) and dynamic plantar aesthesiometer (B) and the effect of apocynin (Apo) treatment on the decreased pain threshold.

Closed circles represent the threshold of DN rats (DN group). Closed squares and closed triangles represent DN rats treated with Apo 30 mg/kg per day (DN + Apo30) and 100 mg/kg per day (DN + Apo100), respectively. Data are presented as the mean ± standard error mean, n = 8–12 rats. The statistical significance of the differences among groups was evaluated by repeated measures of analysis of variance, followed by post-hoc Bonferroni test in the pain threshold tests. #P < 0.05, ##P < 0.01, ###P < 0.01, vs. DN group; $P < 0.05, vs. DN + Apo30 group.