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. 2018 Jul 18;16(4):4773–4781. doi: 10.3892/ol.2018.9168

Table VI.

Performances of cumulative ROC analyses for different combinations of ITGA3, ITGA5, ITGB1 and ITGB6 biomarkers in patients with OSCC.

AUC of combined biomarkers for OSCCa
AUC of combined biomarkers for OSCCa
Locations ITGA3/ITGA5 ITGA3/ITGB1 ITGA3/ITGB6 ITGA5/ITGB1 ITGA5/ITGB6 ITGB1/ITGB6 ITGA3/ITGA5/ITGB1 ITGA3/ITGA5/ITGB6 ITGA5/ITGB1/ITGB6 ITGA3/ITGA5/ITGB1/ITGB6
Allb 0.777 0.775 0.758 0.762 0.720 0.686 0.809c 0.780 0.750 0.797
2/3 0.847 0.829 0.850 0.823 0.792 0.788 0.871c 0.855 0.825 0.870
a

Biomarkers that were more relevant to the OSCC (those with values greater than the cut-off point in AUC of individual ROC results, as demonstrated in Fig. 1), were assigned a score of 1, and the others were assigned a score of 0. The combined scores for different combinations of biomarkers were used for cumulative ROC analysis.

b

All locations including the locations 1, 2, 3, and 4.

c

The best AUC performance among different combinations of biomarkers for OSCC. Location 1, buccal mucosa/retromolar area; location 2, tongue/mouth floor; location 3, edentulous ridge; location 4, others (lower lip/vestibule/soft palate); AUC, area under the curve; ROC, receiver operating characteristics; ITGA3, integrin subunit α3; ITGA5, integrin subunit α5; ITGB1, integrin subunit β1; ITGB6, integrin subunit β6; OSCC, oral squamous cell carcinoma.