Table II.

Univariate and multivariate analysis of factors for OS and DFS in all patients.

A, Association of factors with OS
	Univariate		Multivariate
Variable	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (>35/≤35 years)	0.457 (0.246-0.846)	0.013	0.403 (0.215-0.775)	0.005
Surgical option (conserving surgery/modified radical mastectomy)	0.321 (0.099-1.041)	0.058	0.572 (0.170-1.921)	0.366
TNM stage
I	1 (reference)		1 (reference)
II	4.281 (1.247-14.692)	0.021	3.960 (1.152-13.616)	0.029
III	13.297 (3.978-44.443)	<0.001	11.026 (3.219-37.771)	<0.001
ER (−/+)	1.821 (0.978-3.391)	0.059	2.415 (1.272-4.588)	0.007
PR (−/+)	1.416 (0.749-2.675)	0.284
HER-2 (−/+)	0.648 (0.343-1.226)	0.182
CEA (high/low)	6.128 (3.291-11.409)	<0.001	4.962 (2.647-9.302)	<0.001
CA15-3 (high/low)	2.100 (1.127-3.911)	0.019	1.765 (0.930-3.351)	0.082
B, Association of factors with DFS
	Univariate		Multivariate
Variable	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (>35/≤35 years)	0.728 (0.510-1.039)	0.08	0.702 (0.491-1.003)	0.052
Surgical option (conserving surgery/modified radical mastectomy)	0.800 (0.495-1.292)	0.361
TNM stage
I	1 (reference)		1 (reference)
II	1.290 (0.805-2.068)	0.29	1.236 (0.771-1.983)	0.379
III	3.440 (2.164-5.468)	<0.001	3.206 (1.945-4.960)	<0.001
ER (−/+)	1.268 (0.869-1.849)	0.218
PR (−/+)	1.119 (0.763-1.642)	0.565
HER-2 (−/+)	0.785 (0.536-1.149)	0.214
CEA (high/low)	2.732 (1.792-4.164)	<0.001	2.451 (1.599-3.756)	<0.001
CA15-3 (high/low)	1.608 (1.129-2.291)	0.009	1.389 (0.970-1.988)	0.073

P<0.1 was considered to indicate statistical significance for univariate analysis, and P<0.05 for multivariate analysis. OS, overall survival; DFS, disease-free survival; CI, confidence interval; HR, hazard ratio; TNM, tumor-node-metastasis; ER, estrogen receptor; PR, progesterone receptor; HER-2, human epidermal growth factor receptor-2; CEA, carcinoembryonic antigen; CA, cancer antigen.