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. 2017 Dec 5;1041:187–206. doi: 10.1007/978-3-319-69194-7_10

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© The Author(s) 2017

Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Fig. 10.2 — Ingested material is normally transported unidirectionally. Under certain circumstances, gastric reflux occurs exposing the oesophageal epithelium to stomach secretions that sensitize the tissue. Continued exposure may result in epithelial metaplasia, transforming this squamous tissue in intestinal-like columnar epithelium (Barrett’s oesophagus). This represents a risk factor, predisposing to adenocarcinoma transformation