Skip to main content
. 2018 Sep 3;20(10):1008–1022. doi: 10.1016/j.neo.2018.08.005

Figure 7.

Figure 7

AXL-dependent activation of the AKT-NF-κB pathway is required for upregulation of MCT-1 expression. (A-B) Western blot analysis of AXL, p-AKT (S473), total AKT, p-NF-κB-p65(S536), total NF-κB-p65, and MCT-1 in SK-GT-4-shControl cells (A) or FLO-1-shControl cells (B) versus their respective shAXL cells. (C-D) Western blot analysis of p-AKT (S473), total AKT, p-NF-κB-p65(S536), total NF-κB-p65, and MCT-1 in SK-GT-4 control cells (C) or FLO-1 control cells (D) versus their respective BAY- or MK2206-treated cells. (E-F) Real-time quantitative PCR analysis of MCT-1 mRNA expression in SK-GT-4 control cells (E) or FLO-1 control cells (F) versus their respective BAY-treated cells. Data are represented as mean ± SD.